Syndol sold on PainSelect.com is the original formulation of Syndol (with doxylamine) and is manufactured in South Africa by Adcock Ingram. It contains four active ingredients, paracetamol, codeine phosphate, doxylamine succinate and caffeine. Syndol is medication commonly used for the relief of pain and the reduction of fevers. Paracetamol is a simple painkilling medicine used to relieve mild to moderate pain. Despite its widespread use for over 100 years, we still don't fully understand how paracetamol works to relieve pain. However, it is now thought that it works by reducing the production of prostaglandins in the brain and spinal cord.